204 Proteomics (3 units) Winter
Instructor(s): R. Chalkley Prerequisite(s): Basic background in protein chemistry, or instructor s approval.
Restrictions: Graduate student or instructor s approval. Activities: Lecture
Starting with a review of protein chemistry, emphasizing chemical modification and separation technologies, the course will review current approaches to the study of proteomics and predict what is likely to be realized in the next several years. In addition to the lectures, each student will present a review of a published paper selected by the instructors and write a paper on a topic of current interest to the field (from a list provided, or select their own topic after instructor approval.
219 Special Topics in Basic and Translational Chemical Biology (3 units) Fall, Winter, Spring
Instructor(s): Staff Prerequisite(s): None. Completion of 1st year curriculum in Chemistry and Chemical Biology or another experimental biology graduate program is helpful, but not essential.
Restrictions: Chemistry and Chemical Biology graduate students, other graduate and professional students with interest in Chemical Biology. Permission from instructor is required. Activities: Lecture, Conference, Independent Study
Each course offering will focus on the literature of a current area of Chemical Biology research. Students will be expected to read assigned papers critically before class and to present and discuss papers in class. Students will also be expected to write and present a brief research proposal based upon their reading. Topics in synthetic chemistry, NMR Practical, and Mass Spectroscopy will be covered in separate course offerings.
241 Molecular Thermodynamics (5 units) Winter
This is a course on molecular thermodynamics and statistical mechanics. It covers the concepts of entropy, enthalpy, heat capacity, free energy, ligand binding, solvation, the properties of water, the hydrophobic effect, solution electrostatics, adsorption, and physical and chemical kinetics.
243 Chemical Biology (5 units) Fall
Instructor(s): C. Craik
Basics of chemical biology with a particular emphasis on understanding and manipulating molecular mechanisms of complex biochemical phenomena. Lectures will address macromolecular structure, function, mechanisms, synthesis and metabolism applications.
244 Reaction Mechanisms (3 units) Winter
Instructor(s): J. Gestwicki Prerequisite(s): Graduate standing or consent of instructor.
This course is designed to develop the student's knowledge of organic mechanisms. Thisinteractive course involves some lectures, but enforces student learning through intensive arrow pushing sessions with students at the board. Topics include electrocyclic reactions, Woodward-Hoffman rules, sigmatropic reactions, migration reactions, neighboring group effects, carbanions and free radicals, carbenoids, nitrenes, six-membered heterocyclic rings, five-membered heteroclyclic rings.
297 Chemistry and Chemical Biology Journal Club (1 units) Fall, Winter, Spring
Instructor(s): B. Shoichet Prerequisite(s): None.
Restrictions: None. Activities: Seminar
Readings and conferences based on topics in chemistry and chemical biology. Students are required to present in journal club, once in the first year and once in the second year. This experience will assist students in perfecting communication skills of the scientific literature.