111 How Drugs Work: Physical Principles (2 units) Fall
Restrictions: First year Pharmacy students; others by permission of instructor. Activities: Lecture
This course teaches the fundamentals of thermodynamics, chemical kinetics, and enzyme kinetics, along with their application to biochemical and pharmaceutical systems, including drug discovery and design.
113 Advanced Organic Chemistry (3 units) Winter
Instructor(s): S. Miller
This course lays the foundation for understanding drug action in terms of specifuc interactions between drug molecules and biological targets. It focuses on the chemical and structural properties of the major biological macromolecules that interact with drugs.
114 Intro to Pharm Chem & Drug Metabolism (3 units) Spring
Instructor(s): P. Ortiz de Montellano Prerequisite(s): Pharm Chem 113
A study of physicochemical and biological factors which contribute to drug action; in vivo and in vitro biotransformations of drugs and related organic compounds.
115 Introduction to Pharmaceutical Chemistry and Drug Metabolism (4 units) Spring
Restrictions: none Activities: Lecture
A study of physicochemical and biological factors that contribute to drug action; in vivo and in vitro biotransformations of drugs and related organic compounds.
121 Endocrine & Immunologic Agents (3 units) Fall
Instructor(s): S. Kahl Prerequisite(s): Biochemistry 112 and Pharmaceutical Chemistry 113. Physiology 121 or concurrent enrollment.
The basic focus of this course is consideration of structure-function relationships in various drug classes and their antagonists involved in the treatment of endocrine diseases and in the inhibition of inflammation and immune response. The course is closely coordinated with Pharmacology 121.
123 Drugs of the CNS (4.5 units) Spring
Instructor(s): P. England Prerequisite(s): Consent of instructor.
Restrictions: none Activities: Lecture
This course emphasizes the structure, mechanism and pharmocology of drugs whose primary effects are on the central nervous system. These include: antipsychotics, antidepressants, sediative hypnotics, anticonvulsants, antipiletics, stimulants, drugs of abuse, antiparkinson's drugs, anesthetics, and neurodegenerative diseases. The course provides a basic understanding of the various disorders and the rationale for use of drugs related to current understanding of the disease pathophysiology.
131 Antibiotics and Anticancer Drugs (2.5 units) Fall
Instructor(s): N. Oppenheimer Prerequisite(s): Third-year standing in School of Pharmacy, PharmD program or consent of instructor.
This course focuses on the structure, properties and mechanism of drugs used in antibacterial, antifungal, antiparasitic, antiviral and anticancer therapies. Emphasis is also placed on mechanisms of resistance and means of avoiding or circumventing resistance.
152 Drug Discovery & Design (3 units) Spring
Principles of how new drug are discovered with emphasis on the drug disccovery pipeline, target identification, screening methodologies and assays, mechanism-based design, structure-based design, in vitro and in vivo testing, chemical analoging and development issues. Connections to genomics, pharmacogenetics, bioinformatics, pharmacokinetics and pharmacodynamics, immunology and parasitology and appropriate health science, pharmaceutical industry and clinical issues will be discussed.
157 Bioanalytical Theory & Technique (3 units) Spring
Instructor(s): S. Kahl Prerequisite(s): Spring quarter of third year School of Pharmacy standing or membership in approved graduate program or consent of instructor.
Activities: Lecture, Laboratory
Course covers the theoretical basis, experimental approach and practical aspects of the detection and quantification of drugs and their metabolites in biological samples. Topics include solubility groups, liquid-liquid extractions and sample preparation, spectrophotometric techniques, mass spectrometry, chromatographic theory and techniques, competitive protein binding assays, protein separation, and DNA analysis and sequencing techniques. Laboratory project in a selected area.
163 Pharm Sciences Pathway Seminar (2 units) Winter
Restrictions: None Activities: Lecture
This course will meet weekly and involve a mixture of presentations by students and by faculty and/or outside speakers. The purpose of the course is to provide students with an opportunity to present either a research article or a progress report on their research and to learn about other research opportunities within UCSF and outside. Two classes each quarter will be presented by faculty on their own research and/or research opportunities
165 Pharmaceutical Sci. Pathway Proj.: Pharmaceutical Chemistry (1 - 12 units) Fall, Winter, Spring, Summer
Instructor(s): S. Kahl Prerequisite(s): Successful completion of BIOPHRM SC 134 Research Design.
Restrictions: Pharmacy students must have completed their 3rd year of professional courses or consent of instructor. Activities: Practical Experience
This course is designed to introduce students to research. Students will work closely with a member of the faculty and will focus on a specific project. Students will write a grant for protocol summarizing the work planned, carry out hands-on aspects of the research, analyze results and present findings.
198 Supervised Study (1 - 5 units) Fall, Winter, Spring
Library research and directed reading under supervision of a member of the faculty with the approval of the chairperson of the department.
204 Introduction to Object-Oriented Programming (2 units) Fall
Restrictions: Permission of Instructor. Activities: Lecture
An introduction to object-oriented programming using the Python programming language. During the course, students learn to write, test, and debug programs of increasing complexity. Emphasis is on basic principles in writing well-structured and modular codes. Additional details available on course website: http://www.cgl.ucsf.edu/Outreach/pc204
206 Laboratory Rotation in Pharmaceutical Chemistry (1 - 6 units) Fall, Winter, Spring
Instructor(s): Staff Prerequisite(s): Consent of instructor.
Activities: Laboratory, Project
A laboratory rotation course to familiarize new students in the Graduate Program in Chemistry and Chemical Biology with various approaches to research in the pharmaceutical sciences.
219 Enzyme Mechanisms (3 units) Spring
Instructor(s): S. Miller
In-depth examination of specific enzyme reactions or systems, with emphasis on structure-function.
221 Research Conf in Chem, Chem Biol & Biophysics (1 units) Fall, Winter, Spring
Instructor(s): C. Craik Prerequisite(s): Graduate standing in the Department of Pharmaceutical Chemistry.
A series of weekly research conferences in chemistry, chemical biology and biophysics given by visiting lecturers and faculty.
223 Scientific Communication Seminar (1 units) Fall, Winter, Spring
Instructor(s): C. Craik
This seminar will provide graduate students with a forum in which to develop seminar and poster presentation skills; critically organize and critically review scientific data; and analyze and question oral scientific presentations.
225 Graduate Research Opportunities (1 units) Fall, Winter, Spring
A series of weekly presentations of the research interests of the basic science faculty. The purpose is to acquaint new graduate students with the research in the Departments of Pharmacy and Pharmaceutical Chemistry.
231 Nuclear Magnetic Resonance (3 - 4 units) Spring
Instructor(s): Staff Prerequisite(s): undergraduate physics or physical chemistry.
Theory and application of nuclear magnetic resonance for biomolecular structure determination.
250 Research (1 - 8 units) Fall, Winter, Spring
Activities: Conference, Project
266 Research Planning Conference (1 units) Fall, Winter, Spring
Instructor(s): Staff Prerequisite(s): Consent of instructor
Discussion and practice in research problem formulation and design selection. Core classes and small group sessions are organized around students' interests by faculty within the area of specialization.