152  Drug Discovery & Design  (3 units)   Spring

Instructor(s): M. Arkin       Prerequisite(s): Passing Chemistry 113.

Restrictions: None.       Activities: Direct - Lecture, Student - Lecture

Introduce the process and challenges in discovery of new therapeutics. Topics may include the causes of failure, target selection, methods of compound identification and optimization, intellectual property, and drug development. Class will include lectures, student-led discussion, and in-class workshops/homework. The final class will include student presentations. By the end of the course, students will understand the complex processes leading to the development of novel therapeutics.

157  Bioanalytical Theory & Technique  (2 units)   Spring

Instructor(s): S. Kahl       Prerequisite(s): Spring quarter of third year School of Pharmacy standing or membership in approved graduate program or consent of instructor.

Restrictions: none       Activities: Direct - Lecture, Student - Lecture

Course covers the theoretical basis, experimental approach and practical aspects of the detection and quantification of drugs and their metabolites in biological samples. Topics include solubility groups, liquid-liquid extractions and sample preparation, spectrophotometric techniques, mass spectrometry, chromatographic theory and techniques, competitive protein binding assays, protein separation, and DNA analysis and sequencing techniques.