Course Catalog » Course Listing for Pharmaceutical Chemistry

111  How Drugs Work: Physical Principles  (2 units)   Fall

Instructor(s): X. Shu, J. Gross       Prerequisite(s): None.

Restrictions: First year Pharmacy students; others by permission of instructor.       Activities: Lecture

This course teaches the fundamentals of thermodynamics, chemical kinetics, and enzyme kinetics, along with their application to biochemical and pharmaceutical systems, including drug discovery and design.

113  Advanced Organic Chemistry  (3 units)   Winter

Instructor(s): S. Miller

Activities: Lecture

This course lays the foundation for understanding drug action in terms of specifuc interactions between drug molecules and biological targets. It focuses on the chemical and structural properties of the major biological macromolecules that interact with drugs.

115  Introduction to Pharmaceutical Chemistry and Drug Metabolism  (4 units)   Fall, Spring

Instructor(s): S. Miller, P. Ortiz de Montellano       Prerequisite(s): none

Restrictions: none       Activities: Lecture

A study of physicochemical and biological factors that contribute to drug action; in vivo and in vitro biotransformations of drugs and related organic compounds.

121  Endocrine & Immunologic Agents  (3 units)   Fall

Instructor(s): S. Kahl       Prerequisite(s): Biochemistry 112 and Pharmaceutical Chemistry 113. Physiology 121 or concurrent enrollment.

Activities: Lecture

The basic focus of this course is consideration of structure-function relationships in various drug classes and their antagonists involved in the treatment of endocrine diseases and in the inhibition of inflammation and immune response. The course is closely coordinated with Pharmacology 121.

123  Drugs of the CNS  (4.5 units)   Spring

Instructor(s): P. England       Prerequisite(s): Consent of instructor.

Restrictions: none       Activities: Lecture

This course emphasizes the structure, mechanism and pharmocology of drugs whose primary effects are on the central nervous system. These include: antipsychotics, antidepressants, sediative hypnotics, anticonvulsants, antipiletics, stimulants, drugs of abuse, antiparkinson's drugs, anesthetics, and neurodegenerative diseases. The course provides a basic understanding of the various disorders and the rationale for use of drugs related to current understanding of the disease pathophysiology.

131  Antibiotics and Anticancer Drugs  (2.5 units)   Fall

Instructor(s): N. Oppenheimer       Prerequisite(s): Third-year standing in School of Pharmacy, PharmD program or consent of instructor.

Activities: Lecture

This course focuses on the structure, properties and mechanism of drugs used in antibacterial, antifungal, antiparasitic, antiviral and anticancer therapies. Emphasis is also placed on mechanisms of resistance and means of avoiding or circumventing resistance.

152  Drug Discovery & Design  (3 units)   Spring

Instructor(s): M. Arkin, A. Renslo       Prerequisite(s): Chemistry 113.

Activities: Lecture

Principles of how new drug are discovered with emphasis on the drug disccovery pipeline, target identification, screening methodologies and assays, mechanism-based design, structure-based design, in vitro and in vivo testing, chemical analoging and development issues. Connections to genomics, pharmacogenetics, bioinformatics, pharmacokinetics and pharmacodynamics, immunology and parasitology and appropriate health science, pharmaceutical industry and clinical issues will be discussed.

157  Bioanalytical Theory & Technique  (2 units)   Spring

Instructor(s): S. Kahl       Prerequisite(s): Spring quarter of third year School of Pharmacy standing or membership in approved graduate program or consent of instructor.

Restrictions: none       Activities: Lecture

Course covers the theoretical basis, experimental approach and practical aspects of the detection and quantification of drugs and their metabolites in biological samples. Topics include solubility groups, liquid-liquid extractions and sample preparation, spectrophotometric techniques, mass spectrometry, chromatographic theory and techniques, competitive protein binding assays, protein separation, and DNA analysis and sequencing techniques.

163  Pharm Sciences Pathway Seminar  (2 units)   Winter

Instructor(s): F. Aweeka, M. Gochin       Prerequisite(s): BIOPHRM SC 134

Restrictions: None       Activities: Lecture

This course will meet weekly and involve a mixture of presentations by students and by faculty and/or outside speakers. The purpose of the course is to provide students with an opportunity to present either a research article or a progress report on their research and to learn about other research opportunities within UCSF and outside. Two classes each quarter will be presented by faculty on their own research and/or research opportunities

165  Pharmaceutical Sci. Pathway Proj.: Pharmaceutical Chemistry  (1 - 12 units)   Fall, Winter, Spring, Summer

Instructor(s): S. Kahl       Prerequisite(s): Successful completion of BIOPHRM SC 134 Research Design.

Restrictions: Pharmacy students must have completed their 3rd year of professional courses or consent of instructor.       Activities: Practical Experience

This course is designed to introduce students to research. Students will work closely with a member of the faculty and will focus on a specific project. Students will write a grant for protocol summarizing the work planned, carry out hands-on aspects of the research, analyze results and present findings.

198  Supervised Study  (1 - 5 units)   Fall, Winter, Spring

Instructor(s): Staff

Library research and directed reading under supervision of a member of the faculty with the approval of the chairperson of the department.

206  Laboratory Rotation in Pharmaceutical Chemistry  (1 - 6 units)   Fall, Winter, Spring, Summer

Instructor(s): Staff       Prerequisite(s): Consent of instructor.

Activities: Laboratory, Project

A laboratory rotation course to familiarize new students in the Graduate Program in Chemistry and Chemical Biology with various approaches to research in the pharmaceutical sciences.

219  Enzyme Mechanisms  (3 units)   Spring

Instructor(s): S. Miller

Activities: Lecture

In-depth examination of specific enzyme reactions or systems, with emphasis on structure-function.

221  Research Conf in Chem, Chem Biol & Biophysics  (1 units)   Fall, Winter, Spring

Instructor(s): J. Gestwicki       Prerequisite(s): Graduate standing in the Department of Pharmaceutical Chemistry.

Activities: Conference

A series of weekly research conferences in chemistry, chemical biology and biophysics given by visiting lecturers and faculty.

223  Scientific Communication Seminar  (1 units)   Fall, Winter, Spring

Instructor(s): J. Gestwicki

Activities: Seminar

This seminar will provide graduate students with a forum in which to develop seminar and poster presentation skills; critically organize and critically review scientific data; and analyze and question oral scientific presentations.

225  Graduate Research Opportunities  (1 units)   Fall, Winter, Spring

Instructor(s): J. Gestwicki       Prerequisite(s): Graduate standing in the Department of Pharmaceutical Chemistry.

Activities: Seminar

A series of weekly presentations of the research interests of the basic science faculty. The purpose is to acquaint new graduate students with the research in the Departments of Pharmacy and Pharmaceutical Chemistry.

250  Research  (1 - 8 units)   Fall, Winter, Spring, Summer

Instructor(s): Staff

Activities: Conference, Project

266  Research Planning Conference  (1 units)   Fall, Winter, Spring

Instructor(s): Staff       Prerequisite(s): Consent of instructor

Activities: Conference

Discussion and practice in research problem formulation and design selection. Core classes and small group sessions are organized around students' interests by faculty within the area of specialization.